苯溴马隆因引起几例急性肝衰，在美国被禁止使用。

我们一天就吃个40mg-80mg应该不至于吧

美国还是把别嘌醇作为一线用药

The results showed that overall, Uloric did not increase the risk of these combined events compared to allopurinol (See Data Summary). However, when the outcomes were evaluated separately, Uloric showed an increased risk of heart-related deaths and death from all causes. In patients treated with Uloric, 15 deaths from heart-related causes were observed for every 1,000 patients treated for a year compared to 11 deaths from heart-related causes per 1,000 patients treated with allopurinol for a year. In addition, there were 26 deaths from any cause per 1,000 patients treated for a year with Uloric compared to 22 deaths per 1,000 patients treated for a year with allopurinol. This safety trial was also discussed at a public Advisory Committee meeting of outside experts on January 11, 2019.
心脏相关死亡：别嘌醇是千分之11，非布是千分之15.
各种原因死亡：别嘌醇是千分之22，非布是千分之26.