美国升级版W+NMN（端粒塔）开讲：nmn18000真的有效果吗，nmn18000的功效与作用，NMN研究成果摘录！
nmn18000真的有效果吗，nmn18000的功效与作用，近年来，关于NMN（烟酰胺单核苷酸）的研究，在抗 衰老领域十分火爆。
有多篇学术论 文发表在以Cell（细胞）、Nature（自然）、Science（科学）为代表的权 威学术期刊上，随着研究的不断深入，NMN的抗 衰功能不断被发现，并且更多的研究正在进行中。
那么科学研究已经发现了NMN（美国升级版W+NMN（端粒塔）的哪些功效呢？
nmn18000真的有效果吗，nmn18000的功效与作用，多篇NMN相关的研究论 文发表在权 威学术期刊上
The American upgraded version of W+NMN (telomere tower) lecture: is nmn18000 really effective, the efficacy and role of nmn18000, extracts from NMN research results!
Is nmn18000 really effective? The efficacy and role of nmn18000. In recent years, research on NMN (nicotinamide mononucleotide) has become very popular in the field of anti-aging.
Many academic papers have been published in authoritative academic journals represented by Cell, Nature, and Science. With the deepening of research, the anti-aging function of NMN has been continuously discovered, and more Research is underway.
So what are the effects of NMN (American upgraded version of W+NMN (telomere tower) that scientific research has found?
Is nmn18000 really effective? The efficacy and role of nmn18000. Many NMN-related research papers have been published in authoritative academic journals
1支持NAD＋产生
2013 年，哈佛大学医学院 David Sinclair教 授率领的研究团队通过实验证明，22 个月大的老年小鼠口服NMN一周之后，体内NAD+水平增加，并使线粒体稳态和肌肉功能相关的关键生化指标恢复到相当于6个月大小的年轻小鼠状态，该研究成果发表于《Cell》期刊上。
1 Support NAD+ generation
In 2013, a research team led by Professor David Sinclair of Harvard Medical School proved through experiments that after a week of oral administration of NMN in 22-month-old mice, the level of NAD+ in the body increased, and the key biochemical indicators related to mitochondrial homeostasis and muscle function were restored. to the equivalent of 6-month-old young mice, the research results were published in the journal Cell.
2激 活长寿蛋白SIRTUINS
2019 年，科罗拉多大学博尔德分校综合生理学系de Picciotto N E博士等人研究发现腹腔注射NMN可增加小鼠动脉Sirtuin1活 性并逆转与年龄相关的动脉功能障碍和氧化应激
除了激 活Sirtuin1外，还可以通过其他途径降低老年小鼠的氧化应激并改 善血管功能，例如NMN也可以影响线粒体中Sirtuin3的活 性，降低氧化应激，增强生理功能。
2 Activates the longevity protein SIRTUINS
In 2019, de Picciotto N E, Ph.D., Department of Integrative Physiology, University of Colorado Boulder found that intraperitoneal injection of NMN increased arterial Sirtuin1 activity in mice and reversed age-related arterial dysfunction and oxidative stress.
In addition to activating Sirtuin1, other pathways can also reduce oxidative stress and improve vascular function in aged mice. For example, NMN can also affect the activity of Sirtuin3 in mitochondria, reducing oxidative stress and enhancing physiological functions.
3修 复 DNA 损伤
2017年，哈佛大学医学院David Sinclair教 授率领的研究团队发现NAD+修 复 DNA损伤的机理。随着年龄增长NAD+水平下降，DNA修 复酶PARP1越来越多地被DBC1（乳腺癌缺失因子1）结合形成PARP1-DBC1 复合物，该复合物会阻碍PARP1修 复受损的DNA。
提高NAD+水平会干扰PARP1-DBC1 复合物形成，从而恢复PARP1的DNA修 复 活 性。对暴露于辐射的老年小鼠用口服NMN一周后发现DNA损伤减少。该研究成果发表于《Science》期刊上。
3 Repair DNA damage
In 2017, a research team led by Professor David Sinclair of Harvard Medical School discovered the mechanism by which NAD+ repairs DNA damage. As NAD+ levels decline with age, the DNA repair enzyme PARP1 is increasingly bound by DBC1 (breast cancer deletion factor 1) to form the PARP1-DBC1 complex, which prevents PARP1 from repairing damaged DNA.
Increasing NAD+ levels interferes with PARP1-DBC1 complex formation, thereby restoring the DNA repair activity of PARP1. Decreased DNA damage was found after a week of oral administration of NMN in aged mice exposed to radiation. The research results were published in the journal Science.
4支持新 陈代 谢，促 进能 量产生
新 陈代 谢，是生物体内维持生命的化学反应的集 合，是生物体维持生命的化学反应总称。这些反应使得生物体能够生长和繁殖、保持它们的结构以及对环境作出反应。
代谢是生物体不断进行物质和能 量的交换过程，一旦物质和能 量交换停止，生物体的生命就会结束。
2019 年，马里兰大学医学院Nina Klimova 教 授等人的研究发现，腹腔注射 NMN使实验鼠大脑海马体中线粒体NAD+水平显著增加，脑组织的能 量分子 ATP水平上升，从而提高了机体生物能 量代谢。此外，NMN 还可以提高线粒体中抗 氧化酶的活 性，减少活 性氧的产生。
4 Support metabolism and promote energy production
Metabolism is a collection of life-sustaining chemical reactions in organisms, and is the general term for life-sustaining chemical reactions in organisms. These responses allow organisms to grow and reproduce, maintain their structure, and respond to their environment.
Metabolism is the continuous exchange of matter and energy in an organism. Once the exchange of matter and energy stops, the life of an organism will end.
In 2019, a study by Professor Nina Klimova of the University of Maryland School of Medicine and others found that intraperitoneal injection of NMN significantly increased the level of mitochondrial NAD+ in the hippocampus of the brain of experimental mice, and the level of energy molecule ATP in brain tissue increased, thereby improving the body's biological energy metabolism. In addition, NMN can also increase the activity of antioxidant enzymes in mitochondria and reduce the production of reactive oxyge
nmn18000真的有效果吗，nmn18000的功效与作用，近年来，关于NMN（烟酰胺单核苷酸）的研究，在抗 衰老领域十分火爆。
有多篇学术论 文发表在以Cell（细胞）、Nature（自然）、Science（科学）为代表的权 威学术期刊上，随着研究的不断深入，NMN的抗 衰功能不断被发现，并且更多的研究正在进行中。
那么科学研究已经发现了NMN（美国升级版W+NMN（端粒塔）的哪些功效呢？
nmn18000真的有效果吗，nmn18000的功效与作用，多篇NMN相关的研究论 文发表在权 威学术期刊上
The American upgraded version of W+NMN (telomere tower) lecture: is nmn18000 really effective, the efficacy and role of nmn18000, extracts from NMN research results!
Is nmn18000 really effective? The efficacy and role of nmn18000. In recent years, research on NMN (nicotinamide mononucleotide) has become very popular in the field of anti-aging.
Many academic papers have been published in authoritative academic journals represented by Cell, Nature, and Science. With the deepening of research, the anti-aging function of NMN has been continuously discovered, and more Research is underway.
So what are the effects of NMN (American upgraded version of W+NMN (telomere tower) that scientific research has found?
Is nmn18000 really effective? The efficacy and role of nmn18000. Many NMN-related research papers have been published in authoritative academic journals
1支持NAD＋产生
2013 年，哈佛大学医学院 David Sinclair教 授率领的研究团队通过实验证明，22 个月大的老年小鼠口服NMN一周之后，体内NAD+水平增加，并使线粒体稳态和肌肉功能相关的关键生化指标恢复到相当于6个月大小的年轻小鼠状态，该研究成果发表于《Cell》期刊上。
1 Support NAD+ generation
In 2013, a research team led by Professor David Sinclair of Harvard Medical School proved through experiments that after a week of oral administration of NMN in 22-month-old mice, the level of NAD+ in the body increased, and the key biochemical indicators related to mitochondrial homeostasis and muscle function were restored. to the equivalent of 6-month-old young mice, the research results were published in the journal Cell.
2激 活长寿蛋白SIRTUINS
2019 年，科罗拉多大学博尔德分校综合生理学系de Picciotto N E博士等人研究发现腹腔注射NMN可增加小鼠动脉Sirtuin1活 性并逆转与年龄相关的动脉功能障碍和氧化应激
除了激 活Sirtuin1外，还可以通过其他途径降低老年小鼠的氧化应激并改 善血管功能，例如NMN也可以影响线粒体中Sirtuin3的活 性，降低氧化应激，增强生理功能。
2 Activates the longevity protein SIRTUINS
In 2019, de Picciotto N E, Ph.D., Department of Integrative Physiology, University of Colorado Boulder found that intraperitoneal injection of NMN increased arterial Sirtuin1 activity in mice and reversed age-related arterial dysfunction and oxidative stress.
In addition to activating Sirtuin1, other pathways can also reduce oxidative stress and improve vascular function in aged mice. For example, NMN can also affect the activity of Sirtuin3 in mitochondria, reducing oxidative stress and enhancing physiological functions.
3修 复 DNA 损伤
2017年，哈佛大学医学院David Sinclair教 授率领的研究团队发现NAD+修 复 DNA损伤的机理。随着年龄增长NAD+水平下降，DNA修 复酶PARP1越来越多地被DBC1（乳腺癌缺失因子1）结合形成PARP1-DBC1 复合物，该复合物会阻碍PARP1修 复受损的DNA。
提高NAD+水平会干扰PARP1-DBC1 复合物形成，从而恢复PARP1的DNA修 复 活 性。对暴露于辐射的老年小鼠用口服NMN一周后发现DNA损伤减少。该研究成果发表于《Science》期刊上。
3 Repair DNA damage
In 2017, a research team led by Professor David Sinclair of Harvard Medical School discovered the mechanism by which NAD+ repairs DNA damage. As NAD+ levels decline with age, the DNA repair enzyme PARP1 is increasingly bound by DBC1 (breast cancer deletion factor 1) to form the PARP1-DBC1 complex, which prevents PARP1 from repairing damaged DNA.
Increasing NAD+ levels interferes with PARP1-DBC1 complex formation, thereby restoring the DNA repair activity of PARP1. Decreased DNA damage was found after a week of oral administration of NMN in aged mice exposed to radiation. The research results were published in the journal Science.
4支持新 陈代 谢，促 进能 量产生
新 陈代 谢，是生物体内维持生命的化学反应的集 合，是生物体维持生命的化学反应总称。这些反应使得生物体能够生长和繁殖、保持它们的结构以及对环境作出反应。
代谢是生物体不断进行物质和能 量的交换过程，一旦物质和能 量交换停止，生物体的生命就会结束。
2019 年，马里兰大学医学院Nina Klimova 教 授等人的研究发现，腹腔注射 NMN使实验鼠大脑海马体中线粒体NAD+水平显著增加，脑组织的能 量分子 ATP水平上升，从而提高了机体生物能 量代谢。此外，NMN 还可以提高线粒体中抗 氧化酶的活 性，减少活 性氧的产生。
4 Support metabolism and promote energy production
Metabolism is a collection of life-sustaining chemical reactions in organisms, and is the general term for life-sustaining chemical reactions in organisms. These responses allow organisms to grow and reproduce, maintain their structure, and respond to their environment.
Metabolism is the continuous exchange of matter and energy in an organism. Once the exchange of matter and energy stops, the life of an organism will end.
In 2019, a study by Professor Nina Klimova of the University of Maryland School of Medicine and others found that intraperitoneal injection of NMN significantly increased the level of mitochondrial NAD+ in the hippocampus of the brain of experimental mice, and the level of energy molecule ATP in brain tissue increased, thereby improving the body's biological energy metabolism. In addition, NMN can also increase the activity of antioxidant enzymes in mitochondria and reduce the production of reactive oxyge
